Games such as Metal Gear Solid don't work well with savestates meaning that pressing escape to change to the the disc 2 ISO won't work...you also can't change discs with a CDR plugin and virtual drive as the "tray" never opens meaning that the game will not allow you to proceed. A reasonably simple solution to this is to have F9 and F10 force simulate an opening and closing tray when using a CDR plugin just as they do with ISO's. By doing this alt tabbing out of PCSX-Reloaded to mount the disc 2 ISO on the virtual drive would allow you to change the disc whilst the emulation continues, thus resolving the issue.
Comments: ** Comment from web user: hluo1022 **
Comments: ** Comment from web user: hluo1022 **
Sorry, you are right, I did misunderstand the issue.
I noticed that using savestates in MGS does not work well but I can use in-game save. I also had problem switching disc in MGS. But I then successfully switched to disc II by pausing the game and then ejecting the image. I was just trying to help those who had the same issue with me.